- Poster presentation
- Open Access
Site-specific coupling between aortic pulse wave velocity, carotid vessel wall thickness and peripheral stenosis severity in peripheral arterial occlusive disease at 3T MRI
© van den Bosch et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Pulse Wave Velocity
- Peripheral Arterial Occlusive Disease
- Left Common Carotid Artery
- Aortic Pulse Wave Velocity
- Proximal Aorta
Arterial wall stiffening and thickening are part of the atherosclerosis process leading to luminal narrowing. A close link between distal aortic pulse wave velocity (PWV) and peripheral vascular disease, reflecting site-specific relationship between local plaque burden and vascular disease, is hypothesized. Purpose of this study was to compare peripheral arterial stenosis severity on contrast-enhanced MR angiography (CE-MRA) with regional aortic wall stiffness, expressed by PWV and acquired with velocity-encoded (VE) MRI, and vessel wall (VW) thickness sampled in the left common carotid artery with 3T Black-Blood (BB) MRI.
Linear regression modeling between proximal and distal aortic PWV and carotid VWA/BSA as dependent variables and age and mean peripheral stenosis class (MSC) as predictors
In patients with PAOD, mean peripheral stenosis severity is well-correlated with PWV in the descending to abdominal aorta and to a lesser extent with the carotid vessel wall thickness, while correlation with PWV in the proximal aorta is absent. These findings remain after correction for age, indicating site-specific coupling between aortic wall stiffness and atherosclerotic burden.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.