- Poster presentation
- Open Access
MRI evaluation of vessel wall stretch in healthy and diseased aortas
© Haraldsson et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Wall Shear Stress
- Aortic Wall
- Aortic Stiffness
- Dense Imaging
- Aortic Valve Disease
Mechanical properties of the aortic wall have been used to diagnose and characterize cardiovascular disease. Aortic stiffness correlates with aortic disease and disease progression. Mechanical regulation from strain and wall shear stress is hypothesized to influence remodeling in the cardiovascular system. Current non-invasive techniques for assessing aortic deformation are based on diameter changes, and are sensitive to through-plane motion of the aorta. Conventional methods for assessing strain, such as tagging, have limited resolution. We propose a new MRI approach that measures the regional stretch of the aortic wall itself using displacement encoding with stimulated echoes (DENSE).
Six subjects were studied with standard CINE and DENSE imaging of the tubular portion of the ascending aorta. DENSE was performed at the point of max dilation according to the cine images. The aorta was segmented in the DENSE images and the stretch of the aortic wall was calculated.
This novel application of DENSE imaging allows for direct assessment of regional stretch in the ascending aorta. Clear differences are seen between volunteers and older patients, and within patients depending on the degree of aortic dilation present. Regional differences along the aortic lumen are evident, which cannot be imaged with other techniques. Our pilot study suggests that DENSE may play central wall in better understanding how mechanical differences in the aortic wall interrelate with disease progression.
VA MERIT Review, Covidien/RSNA Research Scholar Grant
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.