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- Open Access
Influence of presence and patterns of late gadolinium enhancement on left ventricular remodeling after heart transplantation
© Braggion Santos et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Cardiovascular Magnetic Resonance
- Late Gadolinium Enhancement
- Heart Transplantation
- Left Ventricular Remodel
The presence of late gadolinium enhancement (LGE) is related to cardiac remodeling and poorer prognosis in ischemic and non-ischemic cardiomyopathies. Non-invasive LGE- cardiovascular magnetic resonance (LGE-CMR) is able to detect infarct-typical and -atypical patterns of LGE after heart transplantation (HTX), mainly due to post HTX coronary artery vasculopathy (CAV) and myocarditis. In this study, we sought to describe the influence of the presence and patterns of both LGE forms on left ventricular (LV) remodeling after HTX.
153 HTX patients were divided into 3 groups depending on the presence and pattern of LGE (group I: atypical pattern, group II: typical pattern and group III: no LGE). 146 patients received coronary angiography within 4 weeks after CMR for assessment of CAV. Vector-ECG gated 32-channel parallel imaging cine SSFP sequences for standard imaging plane and LV volumetry acquisition were acquired on a 1.5T Whole Body MRI scanner (Achieva 1.5T, Philips Medical Systems). LGE-CMR (Gadolinium:0.2 mmol/kg) imaging was performed and analyzed blindly by two experienced observers. Patients were divided according to the presence and patterns of LGE. CAV was divided into three groups:1=mild;2=moderate;3=severe post transplant coronary artery disease. Data were expressed as mean and standard deviation or percentage. Groups were compared using Chi Square for categorical data and ANOVA or Kruskal-Wallis tests for continuous variables. P-values ≤ 0.05 were considered statistically significant.
The presence of infarct-typical LGE-CMR is related to negative post HTX remodeling revealing lower ejection fractions and increased volumes in patients after HTX. Future studies are warranted to evaluate the long-term effect of infarct-typical and atypical patterns on future post HTX outcomes.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.