- Poster presentation
- Open Access
Quantification of left atrial flow velocity distribution in atrial fibrillation using 4D flow MRI
© Fluckiger et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Atrial Fibrillation
- Sinus Rhythm
- Left Atrium
- Thrombus Formation
- Atrial Fibrillation Patient
Atrial fibrillation (AF) is an arrhythmia characterized by irregular electrical activity in the left atrium (LA). Thromboembolism is the most serious complication of AF, usually manifesting as stroke or systemic embolism (1). This is thought to be linked to the increased risk of thrombus formation in the LA due to a decrease in blood velocity (stasis) or flow abnormalities. A better appreciation of the underlying mechanisms and risk factors for thrombus formation in the individual patient are needed to improve risk stratification and therapy planning. Using 4D-flow MRI, time resolved blood velocity measurements can be made in patients with AF. The aim of this study was to compare LA velocity distributions in different groups of AF patients. We hypothesize that persistent AF results in more deranged LA flow patterns with reduced velocities which may be related to an increased risk of thrombus formation and thus stroke.
Using 4D flow MRI we showed that patients with persistent AF have significantly lower LA blood velocity than patients in sinus rhythm. Future work will focus on improving the 4D flow acquisition for regions of low or incoherent flow, using 4D flow to monitor the treatment of patients with AF, and assessing whether flow quantification metrics can serve as biomarkers for stratifying risk of stroke and other AF complications. 1 Wolf et al., Stroke 22. 2 Bernhardt et al. JACC 45(11).
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.