Cardiac magnetic resonance imaging for noninvasive assessment of cardiac allograft during the follow-up of patients after heart transplantation
© Braggion Santos et al; licensee BioMed Central Ltd. 2013
Published: 30 January 2013
Heart transplantation (HTX) is an established life-saving treatment for patients with end-stage heart failure. However, several injuries can compromise cardiac allograft function over the years after HTX, i.e. organ rejection, transplant vasculopathy or infections which can lead to myocardial fibrosis, cardiac remodeling and ventricular dysfunction. Non-invasive late gadolinium contrast enhanced MRI (LGE-CMR) is able to identify myocardial tissue alterations as well as morphological and functional changes. To date, no longitudinal follow-up CMR data on myocardial function and tissue characterization exists on patients after HTX. Therefore, we sought to evaluate longitudinally functional and morphological changes after HTX employing non-invasive LGE-CMR.
The mean time after HTX was 3,8 years for scan1 and 6,4 years scan 2. Although there was a significant increase of LGE for both patterns considering the number of patients affected and numbers of segments involved based on the AHA-17-segment-model, there was no statistical difference in the left ventricular morphology and function. Coronary angiography revealed a statistically significant difference in diagnosed cardiac allograft vasculopathy (CAV) only for CAV0 and CAV3 but not for intermediate lesions (CAV1/2, Figure 1).
The increase of both infarct-typical and -atypical LGE patterns after HTX can be considered as a result of several injuries over the years after HTX. The lack of changes in cardiac morphology and function may be explained by the strict surveillance and early treatment of organ rejection, infections and the advances in the immunosuppressive therapy.
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