- Poster presentation
- Open Access
Analysis of neonatal cardiac function in infants with and without patent ductus arteriosus
© Broadhouse et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Patent Ductus Arteriosus
- Ventricular Dimension
- Common Clinical Presentation
- Enlarge Heart
- Shunt Volume
Scans were performed at 3T using pediatric and extremities coils. Infants were scanned with ear protection, routine monitoring and without sedation/anesthesia. Optimized 2D SSFP short axis 10-slice stacks (resolution=0.5x0.5mm, slice=4mm) were acquired. Segmentation and quantification was carried out using freely available software Segment, the AHA model was used for wall analysis. Description of shunt volume quantification is described previously . The ventricular dimension parameters LVmass, end diastolic volume (EDV), wall thickness and ventricular function parameters of stroke volume (SV), LVO, ejection fraction (EF), and fractional thickening (%thick) were quantified for both "healthy" (control) and PDA infants. The 2 groups were compared using unpaired student t-tests. Impact of shunt volume was analysed with multiple linear regression, p-values ≤ 0.05 being significant. Statistical analysis was carried out in Excel (Microsoft). Starlings curve was plotted to determine effect of PDA.
Although LVO, EDV and LVmass are significantly increased in PDA infants, EF and %thick are not. In addition none of the PDA infants are over the Starlings curve. This would suggest that function is maintained in these enlarged hearts.
MRC UK studentship
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.