- Poster presentation
- Open Access
3D saturation recovery imaging for free breathing myocardial T1 mapping
© Henningsson et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Late Gadolinium Enhancement
- Saturation Pulse
- Free Breathing
- Saturation Recovery
- Breath Hold Acquisition
Longitudinal magnetization relaxation time (T1) mapping can overcome limitations of late gadolinium enhancement for the detection of diffuse fibrosis in the myocardium. Several T1 mapping methods have been proposed in recent years; however most of them are limited to 2D breath-hold acquisitions with associated limitations in signal-to-noise ratio (SNR) and spatial resolution. A MOdified Look-Locker Inversion recovery (MOLLI) approach has been widely used, however systematic T1 errors have been reported which can be overcome by using a Saturation recovery single SHot Acquisition (SASHA). In this work, we extend the 2D SASHA to 3D using a 1D diaphragmatic navigator for respiratory motion correction and segmented k-space acquisitions. The proposed free breathing 3D SASHA method was compared to breath-hold 2D SASHA and 2D MOLLI in healthy volunteers.
The 3D SASHA sequence was implemented as a radiofrequency spoiled gradient echo sequence. Nine 3D images were acquired at different delay times (0 to 700 ms) from the saturation pulses, plus an image acquisition prior to any saturation pulses to estimate the magnetization after an infinite delay. Imaging parameters of the 3D SASHA sequence were; FOV=300×300×80 mm3, spatial resolution=1.5×1.5×8 mm3, α=30°, TR/TE=5.2/2.6 ms, nominal scan time=5:10 min. A 6 mm window and 0.6 tracking factor was used for the respiratory gating and slice tracking. 6 healthy volunteers were scanned on a 1.5T Philips scanner.
3D SASHA allows for accurate T1 quantification of the whole left ventricle in a clinically acceptable scan time. It overcomes the need for breath hold acquisitions and improves the SNR compared to 2D SASHA.
British Heart Foundation: RG/12/1/29262
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