- Poster presentation
- Open Access
Heart-rate independent myocardial T1-mapping using combined saturation and inversion preparation pulses
© Weingärtner et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Relaxation Curve
- Saturation Pulse
- Inversion Pulse
- Phantom Measurement
- Preparation Pulse
Myocardial T1 mapping remains a challenging task due to restrictions imposed by cardiac and respiratory motion. Modified Look-Locker Inversion Recovery (MOLLI)  is widely used for 2D cardiac T1-mapping. In MOLLI, the spin-lattice relaxation curve is sampled several times after a single magnetization preparation. The ECG triggered imaging induces a disturbance in the relaxation curve, which varies based on the heart rate. Hence, MOLLI T1 measurements show strong correlations to the heart rate especially in pre-contrast. We developed a novel T1 mapping sequence that enables heart-rate invariant myocardial T1 mapping.
SAPPHIRE T1-mapping was compared to MOLLI in phantom measurements and in healthy volunteers. A bottle phantom with a T1 of ~1300 ms was imaged using both T1-mapping sequences at various simulated ECGs with different heart-rates. Furthermore, pre-contrast T1-maps in five healthy volunteers were acquired using SAPPHIRE T1-mapping and MOLLI.
SAPPHIRE T1-mapping enables heart rate independent myocardial T1-mapping. The heart-rate invariance is achieved by applying a combination of saturation and inversion pulses as magnetization preparation.
Deutsche Telekom Stiftung; NIH:R01EB008743-01A2; NIH: K99HL111410-01
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