- Poster presentation
- Open Access
T2 mapping in different cardiomyopathies: first clinical experience
© Bönner et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Cardiovascular Magnetic Resonance
- Short Axis Slice
- Left Ventricular Myocardium
- Cardiovascular Magnetic Resonance Imaging
Structural myocardial changes accompany myocardial pathologies such as myocardial ischemia, myocarditis, hypertrophy (HCM) and myocardial remodeling. These changes affect T2 relaxation times which can non-invasively be detected by cardiovascular magnetic resonance imaging (CMR). Since the interpretation of T2 weighted images remains a "risky business" due to subjectivity, the purpose of our study was to evaluate direct T2 value quantification by T2 mapping in different types of cardiomyopathies.
T2 maps were calculated from images recorded with a gated multislice GRASE sequence (9 echos, separated by TE = 7 ms, TR = 750 ms, TA = 5 min, Voxel Size: 2x2x10mm, fat saturation). For creation of T2 maps an exponential decay curve was fitted to the intensity progression of each pixel within the images obtained from the multi echo sequence using a dedicated software based on the graphical programming language LabVIEW (National Instruments, Austin, TX). T2 value distribution in 3 short axis slices (apical, mid-ventricular and basal) were evaluated. Mean, median and standard deviation of values were calculated automatically after manual identification of left ventricular myocardium. T2 maps were analysed in patients with low grade (14-50ng/l) high sensitive troponin T (hsTnT) elevation (n=10), myocarditis (n=10), HCM (n=10) and in a young (mean age: 25 years; n=5) as well as elderly subjects (mean age: 64 years; n=10) without known structural heart disease (control group).
In summary, T2 mapping could be successfully implemented in our clinical routine protocols. We found that (i) there seems to be an age related increase in T2 values in the absence of known cardiac disease and (ii) our sequence is able to identify regions with highly increased T2 values caused by myocarditis or low grade ischemia without any contrast in conventional T2 SPIR or LGE.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.