- Poster presentation
- Open Access
In vivo cardiac diffusion MRI: second order motion compensated diffusion-prepared balanced steady state free precession (SOMOCO Diff Prep bSSFP)
© Nguyen et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Free Precession
- Cardiac Motion
- Excellent Image Quality
- Balance Steady State Free Precession
- Left Ventricle Myocardium
Cardiac diffusion MRI (CDMRI) has the potential to identify acute myocardial ischemia and assess the chronic change of myofiber orientation after a myocardial infarction [1, 2]. Cardiac motion and SNR limitations have been the primary challenges for the application of the technique in vivo. A few previous in vivo studies have demonstrated the feasibility of CDMRI in humans using diffusion-weighted (DW) EPI. However, these approaches suffer from inherently poor SNR efficiency in the case of STEAM DW encoding  or require the use of a reduced field-of-view (FOV) . In addition, they employ a first order motion compensation (MOCO) to account for cardiac motion, while limiting diffusion encoding duration to less than 30 ms to avoid non-constant velocity motion. This severely hinders the ability to achieve an acceptable b-value for CDMRI with clinical hardware limitations. We propose a novel application of diffusion-prepared balanced steady-state free precession (Diff Prep bSSFP)  to include second order MOCO (SOMOCO). This not only allows for sufficiently high b-values, but also takes advantage of the higher SNR efficiency and image quality of bSSFP while ensuring a large FOV.
We have shown the feasibility of using diffusion-prepared acquisitions to derive in-vivo ADC maps of human hearts by employing SOMOCO Diff Prep bSSFP. ADC values acquired from the 11 volunteers are consistent with prior in vivo human cardiac diffusion studies [1, 3, 4]. Further optimization of SOMOCO Diff Prep bSSFP is possible to further increase SNR. We anticipate that shortening the TEprep and 3D imaging may provide opportunities to reach this goal.
National Institute of Health grants nos. NIBIB EB002623 and NHLBI HL38698
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