- Workshop presentation
- Open Access
Motion-robust high-resolution 3D diffusion-weighted vessel wall imaging at 3T
© Xie et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Vessel Wall
- Plaque Component
- Variable Flip Angle
- Vessel Wall Imaging
- Coronary Vessel Wall
Atherosclerotic plaque evaluation has gone beyond simply determining stenosis percentage to characterizing specific plaque components, such as necrotic lipid core and intraplque hemorrhage, in order to detect high-risk subclinical lesions. Diffusion-weighted imaging (DWI) provides excellent contrast-to-noise for identifying plaque components ex vivo  and is shown feasible for in vivo imaging of carotid arterial wall with good correlation to histology . However, current 2D methods based on echo-planar imaging (EPI) have limited resolution, especially in slice-direction, leading to partial volume effects and difficult diffusion quantification. Generally, the use of 3D acquisition improves SNR and resolution at the expense of higher motion sensitivity. The purpose of this work is to develop a high resolution 3D DWI for vessel wall robust to motion.
A novel DWI 3D sequence is implemented for vessel wall imaging with high resolution (0.7×0.7×1.4 mm3) and robustness to motion. Preliminary studies from healthy volunteers at 3T achieved good quality carotid vessel wall images with reasonably high SNR and CNR. ADC values are consistent with previous in vivo  and ex vivo  studies. Blood suppression is satisfactory with inherent TSE black-blood effect combined with extra blood dephasing by the preparation. Real-time motion self-gating prevents motion artifacts. Further study of normal and diseased subjects is warranted. Coronary vessel wall application is under development.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.