- Workshop presentation
- Open Access
Myocardial iron quantification using modified Look-Locker inversion recovery (MOLLI) T1 mapping at 3 Tesla
© Camargo et al; licensee BioMed Central Ltd. 2013
- Published: 30 January 2013
- Iron Overload
- Susceptibility Artifact
- Iron Chelate Therapy
- Myocardial Iron
Quantification of myocardial iron overload is critical for the management of patients with hemochromatosis. The effects of excess iron on T1 and T2* relaxation times correlate directly with tissue iron concentration. T2* became the clinical standard at 1.5T as it can be easily obtained in a fast one breath-hold ECG gated multi-echo GRE sequence. At 3T, however, T2* quantification can be limited by pronounced susceptibility artifacts and signal sampling restraints due to shorter T2* times at higher iron concentrations . Since myocardial T1 time is up to thirty times longer than T2*, it can be quantified with short echo-time inversion-recovery sequences even at high iron concentrations, and is less sensitive to susceptibility artifacts. We aimed to validate a recently developed modified Look-Locker inversion recovery (MOLLI) sequence to quantify myocardial T1 in healthy controls and patients with iron overload at 3T, comparing to standard GRE based multi-echo T2* times at 1.5T.
Myocardial T1 value obtained with a MOLLI sequence has excellent iron quantification capability at 3T.
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