- Moderated poster presentation
- Open Access
Evidence from a multicenter CMR registry indicates that stress CMR imaging provides highly effective risk stratification in patients suspected to have myocardial ischemia
© Patel et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Multicenter Registry
- Patient Risk Stratification
- Standardize Imaging Protocol
- Cumulative Survival Curve
- High Negative Event
A multi-center registry can provide robust real-world evidence regarding CMR diagnostic effectiveness and patient risk stratification, when imaging protocols, data collection, and reporting were standardized. Such evidence from the use of vasodilating stress CMR perfusion is currently limited.
In 2006, we developed a web-based multicenter registry (CMR-Cooperative, CMRCOOP) specific for performance of clinical CMR. This registry aimed to standardize imaging protocol, collection of clinical data, data interpretation, and reporting. All patient identifying information was encrypted. All data was stored and protected by intranet servers and site-specific administrative access. We identified patients who were referred for vasodilating CMR studies with suspected ischemia from 3 major CMR and 1 European centers. Presence of > 1 segment of abnormal stress perfusion without LGE defines ischemia presence and the number of ischemic segments defines ischemia extent. Major hard outcomes (MACE) including all-cause mortality and acute MI were assessed and were associated with CMR evidence of ischemia, using Cox regression.
From this multicenter web-based registry with standardized imaging and data-collection methods, vasodilating CMR demonstrates robust patient risk stratification in patients with suspected ischemia.
No external funding.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.