- Moderated poster presentation
- Open Access
Severity of blood flow reduction associated with detectable T2 enhancement in the area at risk of a reperfused canine model of acute myocardial infarction
© Hammer-Hansen et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Myocardial Blood Flow
- Coronary Occlusion
- Blood Flow Reduction
- Remote Myocardium
- Blood Flow Abnormality
T2-weighted enhancement depicts the myocardial area at risk (AAR) associated with coronary occlusion. However, the severity of blood flow abnormality required to cause a detectable elevation in myocardial T2 is unknown. The aim of this study was to use microspheres to determine the severity of reduction in myocardial blood flow that results in visually detectable T2 weighted enhancement.
Surface coil intensity corrected T2 prepared SSFP at 1.5T was performed after 2 hours of coronary occlusion followed by 4 hours of reperfusion in a canine model. Myocardial blood flow during ischemia was determined by administering microspheres. A mid-ventricular short axis slice of the heart was divided into 16 transmural sectors for microsphere analysis. MR images were matched to the pathological slices at the sector level using papillary muscles and RV insertion as landmarks. ROIs delineated T2-enhanced and remote regions of the MR images and measurements were compared with microsphere blood flows. Results were reported as median (interquartile range [IQ]) and compared using the signed Wilcoxon rank test. Each T2-prepared sector was classified as bright (AAR) or normal (remote) by 2 independent readers and compared with absolute microsphere blood flow and flow relative to remote myocardium. ROC analyses were performed to find the thresholds of absolute and relative blood flow reduction needed to detect T2 enhancement in the sector based analysis.
Sensitivity and Specificity for Determination of T2 Enhancement
16 sector matching (absolute flow)
16 sector matching (relative flow )
24% flow reduction
A relative reduction in blood flow 24% lower than remote myocardium was the best threshold discriminating detectable T2 enhancement in the area at risk. An absolute blood flow reduction below about 0.44-0.50 ml/min/g also predicted T2 enhancement.
Funded by the Intramural Research Program of the National Heart, Lung, and Blood Institute of The National Institutes of Health.
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