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Long-term follow-up of coronary MR and CT angiography for prediction of cardiac events


Although some studies have shown the potential utility of coronary magnetic resonance angiography (CMRA) for the detection of coronary artery disease (CAD), almost no information exists regarding its prognostic value. Aim of our study was to compare the predictive value of CMRA and coronary multislice computed tomography angiography (CCTA) for prediction of cardiovascular events at long-term follow-up, with invasive coronary angiography (ICA) as the reference method.


110 patients referred to MR for suspected or known CAD were prospectively included. A CMRA at 3T, a 64-slice CCTA and an ICA were performed in all patients. A luminal reduction ≥50% was defined as a significant stenosis. All patients were followed up for the occurrence of cardiovascular events, which comprised cardiovascular death, non-fatal myocardial infarction, necessity of revascularization and hospitalization due to cardiac events.


38 events were recorded during a mean follow-up of 40 ± 16 months. No significant differences in event-free survival were observed between the three techniques in the survival analysis (log-rank test p = 0.989) (Figure 1). The area under the receiver-operator curve was 65% (95% CI 55-76, p = 0.009) for CMRA, 70% (95% CI 60-80, p = 0.001) for CCTA and 75% (95% CI 66-85, p < 0.0001) for ICA.

Figure 1
figure 1

Kaplan-Meier curve in patients without significant lesions in coronary magnetic resonance angiography (CMRA), coronary multislice computed tomography angiography (CCTA) and invasive coronary angiography (ICA). No significant differences in outcome are observed.


When assessing long-term prognosis, CMRA and CCTA demonstrated a similar prognostic value compared to invasive coronary angiography for prediction of cardiac events. CMRA has a non-inferior prognostic value compared to CCTA.



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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated.

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Doltra, A., Hamdan, A., Huppertz, A. et al. Long-term follow-up of coronary MR and CT angiography for prediction of cardiac events. J Cardiovasc Magn Reson 16 (Suppl 1), M2 (2014).

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