- Moderated poster presentation
- Open Access
Initial results of a new very rapid rest/regadenoson stress myocardial perfusion protocol in patients with atrial fibrillation
© Chang et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Myocardial Perfusion
- Cardiovascular Magnetic Resonance
- Atrial Fibrillation Patient
- Obstructive Coronary Artery Disease
Cardiovascular magnetic resonance (CMR) myocardial perfusion is a well established method for detection of significant obstructive coronary artery disease (CAD). In patients with arrhythmias, standard methods using ECG-gating can result in poor image quality. Additionally, with typical stress/rest protocols, a true rest state may not be achieved after administration of regadenoson. However, rest-first may present issues with peri-infarct ischemia and so here we give little time for late enhancement by keeping rest and stress perfusion scans close in time. Given these issues, the two-fold aim of this study is to evaluate the accuracy of a rapid rest-first protocol using an ungated myocardial image pulse sequence.
Sensitivity and specificity of this CMR perfusion in the detection of significant coronary lesions were 1 and 0.88, respectively. Average quality of the readings was 3.8 ± 0.8 for both rest and stress perfusion images. Average scan-time for rest/stress perfusion imaging acquisition including time of pharmaceutical injection was 6.5 ± 4.0 minutes.
Initial results for this ongoing rest/regadenoson stress protocol using an ungated myocardial perfusion sequence yielded high sensitivity and specificity for the detection of significant CAD with good image quality. This combination of a novel protocol and an ungated radial sequence addresses the concerns of lingering hyperemia with regadenoson along with problematic gating in arrhythmias.
Astellas Pharma Inc.
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