Extracellular volume assessed by CMR T1-mapping correlates with histologically determined amount of diffuse fibrosis in DCM
© aus dem Siepen et al.; licensee BioMed Central Ltd. 2014
Published: 16 January 2014
Diffuse myocardial fibrosis (MF) in dilated cardiomyopathy (DCM) is closely related to systolic and diastolic cardiac failure and could be identified as a major independent value prediciting clinical outcome. It results from elevated levels of collagen and is therefore associated with an expansion of the extracellular volume (ECV). Up to now, the detection of MF requires myocardial biopsy. Recent reports indicate that CMR T1-Mapping has the potential to detect MF non-invasively. We compared the ECV values derived from T1-mapping with the collagen volume fraction (CVF) as meausured in histological samples.
CMR-based ECV assessment may offer the potential to serve as a non-invasive tool for the quantification of MF in DCM and possibly in other cardiomyopathies as well. Further studies are needed to investigate its impact on clinical outcome prediction in DCM patients.
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