- Oral presentation
- Open Access
MOLLI T1 mapping versus T2 W-SPAIR at 3T: myocardial area at risk measurements and the influence of microvascular obstruction
© Cameron et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Receiver Operator Characteristic
- Acute Myocardial Infarction
- Late Gadolinium Enhancement
- STEMI Patient
- Microvascular Obstruction
Robust CMR imaging is required for the delineation of myocardial area at risk (AAR), so that the success of reperfusion therapies can be evaluated. In this work, we investigate the performance of T1 mapping in assessing AAR one week post-STEMI, and explore the effect of microvascular obstruction (MVO) on T1 relaxation times.
CMR imaging was conducted on a Philips 3T Achieva MRI scanner. T2W-weighted spectral attenuated inversion recovery (T2WW-SPAIR), modified look-locker inversion recovery (MOLLI) T1 mapping and late gadolinium enhancement (LGE) sequences were applied as short axis stacks in 10 healthy volunteers and 62 STEMI patients. Receiver operator characteristic (ROC) analysis was applied to calculate a cut-off T1 to to discriminate AAR from normal myocardium. The presence of LGE was used as the positive ROC test state, while healthy myocardium, as measured in volunteers, was used as the negative ROC test state. For comparison with T1 mapping, the AAR was also measured on T2WW images using a threshold signal intensity > 2SD greater than remote. The derived myocardial edema volumes and salvage indices were compared between MVO+ and MVO- groups.
Area at Risk and Salvage Index
T2W-SPAIR 2SD AAR Volume (%)
T1 Mapping ROC AAR Volume (%)
Salvage Index by T2W-SPAIR 2SD
Salvage Index by T1 Mapping ROC
T1 mapping at 3T can be used to automatically delineate AAR one week post-STEMI. It delimits larger volumes of edema and demonstrates less variability than T2WW-SPAIR. MVO did not significantly affect the discriminatory power of either of these techniques at seven days post-STEMI.
This study was supported by a Medical Research Council (UK) grant, as a sub-study of Nitrites in Acute Myocardial Infarction, NCT01388504.
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