- Oral presentation
- Open Access
Prognostic CMR parameters for heart failure and arrhythmias in large cohort of well treated thalssemia major patients
© Meloni et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Cardiovascular Magnetic Resonance
- Ventricular Dysfunction
- Myocardial Fibrosis
- Cardiac Complication
Cardiac complications are the main cause of death in thalassemia major (TM) patients. Cardiovascular Magnetic Resonance (CMR) plays a key role in their management, assessing myocardial iron overload (MIO), biventricular function, atrial dimensions, and myocardial fibrosis. We evaluated the predictive value of CMR parameters for heart failure and arrhythmias.
We followed prospectively 487 TM patients free of a cardiac complications at the first CMR. All prognostic variables associated with the outcome at the univariate Cox model were placed in the multivariate model and were ruled out if they did not significantly improve the adjustment.
We detected few cardiac events thanks to a MR-guided, patient-specific adjustment of the chelation therapy. Severe and homogeneous MIO, myocardial fibrosis and ventricular dysfunction identify patients at high risk of heart failure. Heart T2* doesn't have any power in predicting arrhythmias while male sex and atrial dilation are independent prognosticators.
The MIOT project receives "no-profit support" from industrial sponsorships (Chiesi and Apopharma). This study was also supported by: "Ministero della Salute, fondi ex art. 12 D.Lgs. 502/92 e s.m.i., ricerca sanitaria finalizzata anno 2006" e "Fondazione L. Giambrone".
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