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Impact of beta-blocker therapy on thoracic aorta 3D wall shear stress in patients with bicuspid aortic valve


Beta-blockers are the recommended medical treatment for slowing ascending aorta (AAo) dilation in patients with bicuspid aortic valve (BAV). Wall shear stress (WSS) has been shown to promote endothelial cell dysfunction [1] and AAo WSS may play a role in aortic aneurysm growth. Time-resolved 3D phase contrast (4D flow) MRI allows for the quantification of 3D WSS regionally in the thoracic aorta. The aim of this study was to assess changes in thoracic aorta WSS associated with β-blocker therapy in BAV patients.


BAV patients on β-blockers (BB+) (n = 10, M:F = 8:2, age: 53 ± 11 years) or not on β-blockers (BB-) (n = 10, M:F = 9:1, age: 51 ± 15 years) underwent 4D flow MRI as part of this IRB-approved study. Groups were matched by BAV morphology (all right-left fusion), systolic blood pressure (BB+: 137 ± 12 mmHg, BB -: 132 ± 17 mmHg, p = 0.48), degree of aortic stenosis, and AAo diameter (BB+: 4.1 ± 0.7 cm, BB-: 3.6 ± 0.4 cm, p = 0.07). Five patients in each group were concurrently treated with ACE-inhibitors or angiotensin receptor blockers. Data analysis included correction for eddy currents and velocity aliasing and 3D segmentation of the thoracic aorta (MIMICS, Materlise, Belgium). Peak systolic WSS (WSSsys) was calculated within the vessel using the method described by van Ooij[2]. The aorta was divided into ascending, arch, and descending regions, and max and mean WSSsys were calculated in each region. WSSsysmaximum intensity projections (MIP) were mapped onto a sagittal view of each aorta for visual comparison. Quantitative results were compared using Student's t-test. Spearman (rS) or Pearson (r) correlation was performed as appropriate.


No statistical difference in max or mean WSSsys was observed between BB+ and BB- groups at any region along the aorta, although values were consistently lower in the BB+ group (Table 1). Max WSSsys in the AAo showed no correlation with aortic diameter (r = .289, p = 0.22) but did correlate with the degree of aortic stenosis (rS = 0.44, p = 0.05). WSSsys MIPs for all subjects are shown in Figure 1. The magnitude and regional distribution of WSSsyswas highly variable between individuals for both groups. Decreased eccentricity of WSSsys in the AAo was observed in BB+ patients.

Table 1 Max and mean peak systolic wall shear stress (WSSsys) regionally along the aorta in bicuspid aortic valve patients being treated with beta-blockers (BB+) or not receiving beta-blockers (BB-).
Figure 1
figure 1

Peak Systolic Wall Shear Stress (WSS sys ) maximum intensity projections in the study cohort. Values for WSSsys are in N/m2. Note that there is a large variation across both groups in terms of WSSsys values and where the maximum WSS is located. In general, patients appear to have WSSsys angled toward the lateral wall of the ascending aorta, however, there appears to be fewer patients with this eccentric WSS distribution in the β-blocker group (BB+).


Our results suggest that the impact of β-blocker therapy on the degree of WSS in the thoracic aorta is limited, but treatment may alter AAo WSS distribution. The high inter-individual variability of 3D WSS highlights the potential diagnostic value of 4D flow MRI WSS quantification for individualized assessment β-blocker effectiveness in BAV aortopathy. A prospective study in a large number of patients pre- and post-treatment is required to better isolate the impact of β-blockers in this population.


NIH NCI 5R25CA132822-04, NIH NHLBI R01HL115828; AHA13SDG14360004, BAV Program at the Bluhm Cardiovascular Institute.


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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Allen, B.D., van Ooij, P., Barker, A.J. et al. Impact of beta-blocker therapy on thoracic aorta 3D wall shear stress in patients with bicuspid aortic valve. J Cardiovasc Magn Reson 16 (Suppl 1), O47 (2014).

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