- Oral presentation
- Open Access
Electromechanical and scar characteristics at left ventricular lead implant site in the context of overall dyssynchrony with cine DENSE predict cardiac resynchronization therapy outcomes
© Bilchick et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Cardiac Resynchronization Therapy
- Late Gadolinium Enhancement
- Left Bundle Branch Block
- Mechanical Dyssynchrony
- Left Ventricular Lead
In clinical patients undergoing cardiac resynchronization therapy (CRT), myocardial properties (mechanical, electrical, and scar-mediated) at the left ventricular (LV) lead position (LVLP) and overall LV dyssynchrony (circumferential uniformity ratio estimate [CURE, 0-1]) are of interest with respect to CRT outcomes. We sought to define the relative importance of these factors for CRT response in a clinical CMR study with longitudinal follow-up.
Mechanical, electrical, and scar properties at the LVLP and overall mechanical dyssynchrony based on CURE provide highly accurate prediction of LV reverse remodeling after CRT. CMR DENSE and LGE are very useful for pre-CRT assessment of heart failure patients.
This research was supported by Dr. Bilchick's NIH K23 grant HL094761 and Dr. Holmes' R01 grant HL085160.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.