Skip to content

Advertisement

  • Oral presentation
  • Open Access

Native T1 values in discrimination between in acute and chronic myocarditis

  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 2,
  • 1,
  • 1 and
  • 1
Journal of Cardiovascular Magnetic Resonance201416 (Suppl 1) :O62

https://doi.org/10.1186/1532-429X-16-S1-O62

  • Published:

Keywords

  • Cardiovascular Magnetic Resonance
  • Myocarditis
  • Chronic Stage
  • Myocardial Oedema
  • Acute Myocarditis

Background

T1 mapping by cardiovascular magnetic resonance (CMR) provides tissue-dependent relaxation times in line with the underlying myocardial composition. In this study, we examined the value of native T1 in differentiation between acute viral myocarditis and chronic stages of healing.

Methods

Fifty-three patients with a clinical diagnosis of acute viral myocarditis were compared to fifty-six subjects in clinical convalescence. All subjects underwent assessment of myocardial oedema, function and scar by CMR at 1.5 and 3-Tesla. T1 values were measured in midventricular short-axis slice prior to and after administration of 0.2 mmol/kg of gadobutrol.

Results

Compared to controls (n = 40), native T1 values were increased in both acute and chronic myocarditis at both field strengths (controls vs. acute vs. chronic myocarditis; 1.5T: native T1 (msec): 940 ± 17 vs. 1070 ± 34 vs. 998 ± 28, p < 0.001; 3T: 1045 ± 18 vs. 1182 ± 66 vs. 1094 ± 15, p < 0.001). Native T1 values were significantly higher in acute vs. chronic myocardium (p < 0.001). Native T1 was identified as the independent discriminator between health and disease, as well as acute and chronic myocarditis (Figure 1). Native T1 showed gradual reduction of values between acute and chronic stage of myocardial inflammation.
Figure 1
Figure 1

Native T1 is superior to LGE and T2 enhancement in discrimination between acute and chronic myocarditis.

Conclusions

We demonstrate that native T1 values can reliably discriminate between patients with acute myocarditis and those subjects in stages of chronic healing at both field strengths. Native T1 values provide a dynamic index of disease activity and progression from acute disease towards clinical resolution.

Funding

We would like to acknowledge Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital National Health Service Foundation Trust. Dr. Rocio Hinojar was supported by the Spanish Society of Cardiology.

Authors’ Affiliations

(1)
King's College London, London, UK
(2)
Philips Healthcare, Guilford, UK

Copyright

© Baydes et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Advertisement