- Oral presentation
- Open Access
Cine DENSE MRI detects delayed mechanical activation of the left ventricular free wall in a canine model of heart failure with left bundle branch block
© Cui et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Cardiac Resynchronization Therapy
- Leave Bundle Branch Block
- Mechanical Dyssynchrony
- Ventricular Free Wall
- Left Ventricular Free Wall
Cardiac resynchronization therapy (CRT) benefits selected heart failure patients; however, CRT has a non-response rate of approximately 30-40%. Important factors that contribute to lead placement decisions and overall CRT success include determination of mechanical dyssynchrony, presence and location of scar, and the identification of late-activated segments. Recent imaging studies have reported progress in the first two areas. Previously, myocardial tagging showed promise for mapping mechanical activation time , but analysis of tagged images is time consuming. We investigated the use of cine DENSE to detect regions of late mechanical activation.
Cine DENSE provides sufficient spatial and temporal resolution of LV strain to quantify the propagation of mechanical activation over the LV in a canine model of heart failure and LBBB. The time required to analyze cine DENSE data is much less than for conventional tagging, and completely automated methods have recently been described . Cine DENSE shows promise for quantifying the extent of mechanical dyssynchrony , and identifying late-activated regions that would be good candidate sites for LV lead implantation.
NIH K23 grant HL094761 and American Heart Association Grant-in-Aid 12GRNT12050301
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