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High-resolution T2 relaxometry detects intramyocardial hemorrhage post myocardial infarction in swine
Journal of Cardiovascular Magnetic Resonance volume 16, Article number: O71 (2014)
Intramyocardial hemorrhage (IMH) secondary to myocardial infarction (MI) is associated with adverse prognosis . The byproducts of blood breakdown lead to decreases in T2 and T2*, and have been shown to be related to microvascular obstruction (MVO) as detected by early contrast enhanced (EGE) imaging . However, EGE is heavily influenced by contrast agent kinetics and measures the lack of contrast agent penetrance rather than IMH directly. Here, we present high-resolution T2 mapping for accurate assessment of IMH without the need for contrast agents. Hypothesis: Quantitative high resolution T2 mapping can detect IMH, without the need for contrast agents.
MI was induced by 120 min LAD occlusion and reperfusion in 5 Yorkshire swine. Imaging was performed 5-9 days post MI using a 3T system (Achieva TX, Philips Healthcare). Breath-hold black-blood T2W turbo spin echo imaging (BB-T2-STIR)  and 3D respiratory navigator gated T2-mapping  were acquired. EGE images (phase sensitive inversion recovery ) were also acquired post infusion (0.2 mmol/kg, Magnevist). 3D T2 maps were calculated per voxel using linear regression of the log of the signal and poor fits (R2 < 0.9) were rejected. IMH was identified in T2W images/T2 maps by areas of hypointense signal/T2 surrounded by hyperintense signal/T2 representing edema. MVO was defined in EGE images by a hypointense area surrounded by enhanced MI. After MRI acquisitions hearts were excised and post-mortem pathology and histology were obtained.
IMH was detected in 4 (out of 5) animals by T2 mapping which was confirmed by histology. Findings on T2W images were variable due to prominent artifacts from slow flow or motion, though signal heterogeneity was observed (Figure 1). MVO was detected from EGE though MVO varied with time post contrast injection. T2 mapping showed excellent correlation with the myocardial distribution of IMH as evidenced by reduced T2 and the correlation with MVO. (Figure 2) Based on ROI analysis, T2 in IMH was significantly lower than that of remote myocardium (36.5 ± 4.6 ms v.s. 45.7 ± 1.1 ms, p = 0.02).
High-resolution T2 imaging allows for accurate assessment of IMH without the temporal variability imposed by the contrast agent kinetics of EGE, or the known artifacts associated with BB-T2-STIR.
This work was funded in part by AHA-11SDG5280025.
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Ding, H., Schuleri, K.H., Schär, M. et al. High-resolution T2 relaxometry detects intramyocardial hemorrhage post myocardial infarction in swine. J Cardiovasc Magn Reson 16, O71 (2014). https://doi.org/10.1186/1532-429X-16-S1-O71
- Microvascular Obstruction
- Post Myocardial Infarction
- Phase Sensitive Inversion Recovery
- Respiratory Navigator
- Intramyocardial Hemorrhage