- Oral presentation
- Open Access
High-resolution T2 relaxometry detects intramyocardial hemorrhage post myocardial infarction in swine
© Ding et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Microvascular Obstruction
- Post Myocardial Infarction
- Phase Sensitive Inversion Recovery
- Respiratory Navigator
- Intramyocardial Hemorrhage
Intramyocardial hemorrhage (IMH) secondary to myocardial infarction (MI) is associated with adverse prognosis . The byproducts of blood breakdown lead to decreases in T2 and T2*, and have been shown to be related to microvascular obstruction (MVO) as detected by early contrast enhanced (EGE) imaging . However, EGE is heavily influenced by contrast agent kinetics and measures the lack of contrast agent penetrance rather than IMH directly. Here, we present high-resolution T2 mapping for accurate assessment of IMH without the need for contrast agents. Hypothesis: Quantitative high resolution T2 mapping can detect IMH, without the need for contrast agents.
MI was induced by 120 min LAD occlusion and reperfusion in 5 Yorkshire swine. Imaging was performed 5-9 days post MI using a 3T system (Achieva TX, Philips Healthcare). Breath-hold black-blood T2W turbo spin echo imaging (BB-T2-STIR)  and 3D respiratory navigator gated T2-mapping  were acquired. EGE images (phase sensitive inversion recovery ) were also acquired post infusion (0.2 mmol/kg, Magnevist). 3D T2 maps were calculated per voxel using linear regression of the log of the signal and poor fits (R2 < 0.9) were rejected. IMH was identified in T2W images/T2 maps by areas of hypointense signal/T2 surrounded by hyperintense signal/T2 representing edema. MVO was defined in EGE images by a hypointense area surrounded by enhanced MI. After MRI acquisitions hearts were excised and post-mortem pathology and histology were obtained.
High-resolution T2 imaging allows for accurate assessment of IMH without the temporal variability imposed by the contrast agent kinetics of EGE, or the known artifacts associated with BB-T2-STIR.
This work was funded in part by AHA-11SDG5280025.
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