- Oral presentation
- Open Access
Fast three-dimensional black-blood MR imaging for carotid artery intra-plaque haemorrhage using DANTE-prepared FLASH (3D-DASH)
© Li et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Longitudinal Magnetization
- Isotropic Resolution
- Double Inversion Recovery
- Vessel Wall Imaging
- Oxford Biomedical Research
DANTE (Delays Alternating with Nutation for Tailored Excitation) pulse trains are a rapid series of low flip angle RF pulses interspersed with gradients. We have previously demonstrated that when using DANTE pulse trains as a preparation module prior to imaging readout, the longitudinal magnetization of flowing spins is substantially attenuated, whereas the longitudinal magnetization of static tissue/fluid is mostly preserved . In this study we introduce a new DANTE-prepared 3D FLASH T1 weighted (T1w) sequence (denoted '3D-DASH') that is able to generate 0.6 mm isotropic resolution images with an average imaging speed better than 2 sec/slice.
6 healthy volunteers (males, 24 to 35 years) underwent (i) DIR (double inversion recovery)-prepared 2D-TSE, (ii) 3D-DASH and (iii) comparison MSDE prepared FLASH, 3D-MERGE, imaging. 4 symptomatic patients (age range, 54-86) scheduled for carotid endarterectomy (> 70% stenosis measured by ultrasound) underwent the same vessel wall imaging protocol. Written informed consent was obtained from all subjects. All scans were acquired using a 3T Siemens Verio scanner. A pair of dual-channel surface coils (Machnet, The Netherlands) were used. Cardiac gating was used for comparison DIR-prepared black blood scans. Protocol: axial imaging acquisition, identical 3D FLASH readout sequences for 3D-DASH and 3D-MERGE, FOV = 150 × 150 mm, matrix size 256 × 252, interpolated to 512 × 512, partition thickness = 0.6 mm, Number of averages = 2, iPat = 2, slices = 128, FLASH flip angle α = 10°, slice resolution = 63%, phase and slice partial FT = 6/8, Fat suppression = water excitation-fast, TRinternal = 10 ms, BW = 130 Hz/pixel, resolution = 0.6 mm isotropic. Parameters for the DANTE module: flip angle (FA) α = 15°; Number of pulses Np = 150; time duration between DANTE pulses, tD = 1 ms; Gx, y, z = 20 mT/m; gradient duration≈1 ms.
3D-DASH is a promising new sequence for 3D isotropic (0.6 mm) fast black-blood T1 weighted imaging of the carotid arteries with high sensitivity to intra-plaque haemorrhage.
We thank the NIHR Oxford Biomedical Research Centre, BHF, and Dunhill Medical Trust for grant funding.
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