- Oral presentation
- Open Access
Comparison of white blood and black blood T2* cardiovascular magnetic resonance at 3 Tesla
© Alam et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Cardiovascular Magnetic Resonance
- Black Blood
- Myocardial Iron
- Hereditary Haemochromatosis
T2* relaxometry offers a non-invasive method to accurately quantify myocardial iron levels, thus aiding the diagnosis and assessment of prognosis of patients. Two T2* sequences are used clinically: the single breath-hold multi-echo gradient echo white blood (WB) and black blood (BB) techniques. At 1.5T, BB T2* has superior reproducibility and fewer artefacts than WB T2*. We compared BB and WB T2* iron measurement at 3T and compared results with corresponding 1.5T measurements.
We recruited 100 patients (55 male, aged 14 to 81 years) referred for iron assessment (thalassemia major 43, sickle cell disease 15, hereditary haemochromatosis 11, other iron overload conditions 31). The same mid-ventricular short axis slices were used to generate both BB and WB T2* images at 1.5T (Avanto, Siemens, Erlangen, Germany), and similarly at 3T (Skyra). 20 patients underwent repeat studies on the same day for reproducibility. Septal regions of interest were analyzed using CMRtools, using the truncation algorithm. All patient images were ranked for artefact severity on an ordinal scale from 0 (uninterpretable images) to 5 (no septal artefact).
At 3T, BB T2* is superior to WB T2* for artefacts, noise and reproducibility, which accords with experience at 1.5T. The 3T BB T2* values correlate well with gold standard 1.5T T2* with values approximately halved. Considerable further experience with BB T2* is needed before robust clinical practice can be recommended
This research was supported by the NIHR Cardiovascular Biomedical Research Unit at Royal Brompton & Harefield NHS Foundation Trust and Imperial College London.
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