- Oral presentation
- Open Access
Evaluation of iron overload: dual-energy computed tomography versus magnetic resonance imaging
© Ibrahim and Bowman; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Iron Overload
- Hounsfield Unit
- Myocardial Iron
- Myocardial Iron Overload
- Induce Heart Failure
Iron toxicity is key factor for tissue damage in iron-overloaded patients, with induced heart failure as the main cause of death. T2*-weighted MRI has been established as the method of choice for evaluating iron-content with strong correlation with biopsy, where T2* < 20 ms and T2* < 10 ms at 1.5T indicate iron overload and severe iron overload, respectively. Recently-introduced dual-energy CT (DECT) has the potential for evaluating iron overload without energy-dependent CT attenuation or tissue fat effects. The aim of this study is to investigate the performance of DECT for iron mapping in in-vitro scans of calibrated iron phantoms and compare results to MRI.
Ten 50-mL agarose phantoms(tubes) were created to mimic myocardial T1&T2 with different iron contents:0-4.5 g. The phantoms were imaged on Siemens 1.5T-MRI and DECT scanners. A GRE MRI sequence was used with 12-echoes (TE = 1-16 ms), 2.8 mm resolution, and 19 s scan-time. Two DECT scans were conducted with 80/140 kVp and 100/140 kVp, 0.3 mm resolution, and 2 s scan-time. 2-cm2 ROI's were used to measure average signal intensities in MRI and Hounsfield Units (HU) in CT. The values from MRI images were fitted to mono-exponential curves to measure T2* and R2* (= 1/T2*). Correlation analysis was conducted between iron-content, R2*, and HU values/differences/ratios at different energies (the 120 kVp-image automatically calculated by the scanner). Two tubes had T2* = 10 ms and 21 ms, which were used to identify boundaries between different iron-overload categories.
DECT can be used for iron quantification with high accuracy similar to MRI, which might help in patient staging, independent of the energy level. New DECT scanners with low radiation-exposure, much shorter scan-time, and higher capability of measuring large iron-contents compared to MRI, may provide promising approach for evaluating myocardial iron overload.
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