- Poster presentation
- Open Access
Quantification of septal and whole slice myocardial blood flow by myocardial perfusion CMR is similar in healthy volunteers
© Erhayiem et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Myocardial Blood Flow
- Myocardial Perfusion Reserve
- British Heart Foundation
- Volume Artefact
- Stress Myocardial Blood Flow
First pass myocardial perfusion CMR allows quantification of myocardial blood flow (MBF). MBF estimation with whole-heart tissue response may be useful in a variety of systemic diseases, but can be limited by suboptimal imaging in one or more segments. The interventricular septum (IVS) offers an attractive target for MBF imaging, as it offers higher signal and less partial volume artefact from blood pool. It has been proposed that T1 measurements taken from the IVS are more reliable than measurements from an entire short axis slice. We hypothesised that MBF estimation from the IVS would be similar to whole-heart estimation.
Nine healthy volunteers underwent CMR at 3.0T (Philips Achieva TX, 32 channel receiver coil). First-pass perfusion imaging in three short-axis LV slices was performed during administration of 0.075 mmol/L/kg of gadobutrol at basal, mid-ventricular and apical short-axis slices. This protocol was performed following 3 minutes of 140 mcg/kg/min adenosine for stress perfusion and repeated 15 minutes later at rest. MBF estimation was performed using Fermi deconvolution (PMI v.0.4, [Sourbron, 2009]) with basal blood pool providing the arterial input. Tissue response with whole mid-ventricular myocardium and limited IVS contours were compared. Myocardial perfusion reserve (MPR) was calculated by dividing stress MBF by rest MBF. Adequate hemodynamic response was defined as heart rate increase ≥10/min or blood pressure decrease ≤10 mmHg or presence of significant chest discomfort or dyspnoea.
Limited septal quantification of MBF is similar to whole-heart region of interest. This technique may simplify MBF estimation for those with suboptimal imaging outside of the septum or low myocardial signal.
JPG and SP receive a research grant from Philips Healthcare. SP is funded by British Heart Foundation fellowship (FS/10/62/28409).
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