Peripheral perfusion index measured using magnetohydrodynamic voltages in 3T MRI
© Gregory et al.; licensee BioMed Central Ltd. 2014
Published: 16 January 2014
The Peripheral Perfusion Index (PFI) has been utilized for early detection of impaired organ perfusion in order to avoid tissue hypoxia, which could lead to organ failure . A decrease in effective circulating blood volume, lowering of PFI levels, can cause vasoconstriction . Strong MRI magnetic field (B0) interactions with flowing blood plasma electrolytes produce a Magnetohydrodynamic voltage (VMHD) . We hypothesized that a processing method which derives VMHD at different segments of the body could provide a direct indicator for PFI as well as local perfusion levels in various body regions. Existing methods for PFI estimation include Pulse Oximetry (PO) and differential temperature recordings, both of which are indirect measurements .
SP varied over different body segments, with major blood vessels corresponding to greater changes in SP (Figure 1d). Fluctuations in SP were observed at the thigh-hip complex, kidneys, aorta, and head, which were attributed to the common iliac, renal, aortic, and carotid arteries, respectively. When the direction of the blood flow aligned with B0, SP was minimized, such as in the case of the abdominal aorta (Figure 1d). PFI was determined to be 1.98, within the normal range of 1.18-2.5 .
VMHD processing using this method exhibits characteristic SP patterns and perfusion levels for each body segment. Measured PFI levels were comparable to normal values. Future work includes comparison of the processing result with paired PO-based PFI measurements.
NIH U41-RR019703, NIH R03 EB013873-01A1, SBIR-1 R43 HL110427-01.
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