- Poster presentation
- Open Access
T1 and T2 mapping detect myocardial edema after repeated 200J electrical cardioversion
© Guensch et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Myocardial Injury
- Myocardial Edema
- Electrical Cardioversion
- Remote Myocardium
- Post Shock
Electrical defibrillation and cardioversion are important and sometimes life-saving interventions. However, it remains controversial whether the intervention itself can significantly damage the heart. Myocardial edema is an early feature of myocardial injury that can be visualized by T2-weighted sequences. Newer approaches utilize T2 as well as T1 mapping techniques. We used T1 and T2 mapping to detect edema as a marker for defibrillation injury.
Using a 3T clinical MRI system, we assessed 10 anesthetized pigs at baseline and hourly for 5 hours after 5 consecutive synchronized transthoracic shocks of 200J and acquired images for T1 maps (MOLLI, modified look-locker inversion recovery) and T2 maps in three short-axis planes; basal, mid and apical. Six pigs undergoing the same protocol yet without shocks served as controls. After euthanasia and explantation of the hearts, tissue samples were obtained from regions of interest (ROI) defined by positive CMR results. Hematoxylin and eosin (HE) stains of these samples were then assessed for intercellular and interstitial edema using randomly sampled planimetry.
Repeated cardioversion/defibrillation consistently leads to cellular and interstitial myocardial and skeletal edema, which can be visualized by T1 mapping and T2 mapping.
Funding is provided by the Montreal Heart Institute Foundation and the Canadian Foundation for Innovation.
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