- Poster presentation
- Open Access
Reproducibility of multiple T1 Mapping techniques and to ECV quantification
© Yingchoncharoen et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Intraobserver Variability
- Extracellular Volume
- Reproducible Technique
- Minimal Detectable Change
T1 Mapping has emerged as a new marker to quantify myocardial extracellular volume (ECV), which is typically increased in the setting of diffuse fibrosis or infiltrative heart diseases. However the reproducibility of the technique is largely unknown. We sought to identify the interobserver, intraobserver variability of different T1 mapping techniques as well as validation of one technique against the standard technique for ECV quantification.
We selected 10 patients with the diagnosis of cardiomyopathy (5 with delayed contrast enhancement and 5 without). The Look-Locker (LL) and Modified Look-Locker both precontrast (MOLLI_Pre) and postcontrast (MOLLI_Post) T1 time were measured by 3 investigators blinded to clinical data at 2 different time points. Interobserver and Intraobserver reproducibility were assessed using 2-way ANOVA approach. The ECV was calculated using pre and post contrast T1 and hematocrit.
Interobserver and intraobserver variability of LL, MOLLI_Pre, MOLLI_Post and ECV
Min Δ detectable
Min Δ detectable
Both LL and MOLLI are highly reproducible technique. LL was strongly correlated with post-contrast MOLLI which is moderately correlated to ECV.
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