- Poster presentation
- Open Access
Myocardial oxygenation is reduced in end-stage renal failure: a novel blood oxygen level dependant (BOLD)-cardiac MRI study
© Parnham et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Cardiovascular Magnetic Resonance
- Chronic Renal Failure
- Blood Oxygen Level Dependant
- Blood Oxygen Level Dependant Signal
- Chronic Renal Failure Patient
Cardiovascular disease is the leading cause of mortality and morbidity in end-stage renal failure (ESRF) population, mostly from coronary artery disease (CAD). Majority of CAD in ESRF patients is asymptomatic and current cardiac stress imaging modalities are sub-optimal as risk predictors. Advances in cardiovascular magnetic resonance (CMR) with the novel blood oxygen level-dependent (BOLD) technique provides unprecedented capability to assess regional myocardial deoxygenation. We hypothesized that myocardial oxygenation would be reduced in ESRF patients and may form a novel strategy to assess myocardial ischemia.
Sixteen chronic renal failure (CRF) patients (7 on dialysis, 9 pre-dialysis) with no known history of CAD underwent CMR scanning at 3.0 T. Given known reductions in BOLD signals in hypertrophied myocardium, we also assessed a control group of HT patients with no history of CAD (n = 6) Myocardial function, rest and stress BOLD was performed. To measure oxygenation, using a T2-prepared BOLD sequence, myocardial Signal Intensity (SI) was measured at adenosine stress (140 μg/kg/min) and at rest (corrected to RR interval). Comparison of myocardial SI analyses were performed using multivariate linear regression.
Myocardial Oxygenation in Left Anterior Descending (LAD), Left Circumflex (LCx) and Right Coronary Artery (RCA) Territories
BOLD SI Change
(n = 16)
(n = 6)
-1.79 +/- 9.13
17.36 +/- 9.19
-3.08 +/- 14.37
18.97 +/- 2.39
1.49 +/- 13.66
14.29 +/- 18.74
-5.03 +/- 8.47
17.21 +/- 12.21
Chronic renal failure patients have global reductions in myocardial oxygenation even controlling for the degree of LVH. BOLD CMR is a promising tool to detect myocardial ischemia in the renal failure population, and may form a novel risk predictor of cardiovascular prognosis.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.