- Poster presentation
- Open Access
Cine delayed hyper-enhancement CMR imaging without additional scan time
© Hassanein et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Functional Information
- Circumferential Strain
- Cine Image
- Motion Field
- Myocardial Scar
A typical CMR exam includes cine, tagging, first-pass, and delayed-hyper-enhancement (DHE) imaging. The DHE image is usually acquired at a single timeframe. Nevertheless, obtaining cine DHE images would provide both viability and functional information in single set of images without misregistration problems for better image interpretation. However, repeated breath-hold scans are required to obtain cine DHE images, which increases scan-time with varying level of tissue enhancement with time. In this work, we propose a new technique for generating cine DHE images based on the acquired DHE image and motion field derived from the corresponding tagged images.
A mid-diastolic short-axis DHE image and the corresponding set of tagged images were acquired on 3T-MRI scanner. The corresponding cine images were acquired for reference. Image analysis has two steps: 1) apply the Lucas-Kanade optical-flow algorithm to the tagged images to extract the motion field of the myocardium through the cardiac cycle; 2) apply the measured motion field to the known (acquired) DHE image to generate the unknown DHE images. The infarcted regions were identified in the DHE images using the full-width at half-maximum method. Radial thickening was measured from both cine and DHE images to evaluate the generated images. Infarction transmurality, circumferential strain, and radial thickening were measured from the DHE, tagged, and cine images, respectively, and the relationships between the generated parameters were studied using regression and correlation analyses.
The developed technique generates composite images that show both viability and functional information in one set of images, which is important for prognostic evaluation of the patient's condition, e.g. determining candidates for revascularization. The generated images could be also useful for differentiating between gadolinium recess in the muscle and myocardial scar, usually conducted by comparing cine and DHE images side-by-side. Future work includes further improvement of the optical-flow algorithm to minimize error propagation with time, and implementing the algorithm on large number of patients with different degrees of infarction.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.