- Poster presentation
- Open Access
CMRSegTools: an Osirix plugin for myocardial infarct sizing on DE-CMR images
© Viallon et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Infarct Size
- Gaussian Mixture Model
- Segmentation Framework
- Contour Segmentation
- Infarct Lesion
CMR is an established method for the diagnosis and assessment of myocardial infarction in routine exams. In addition, there has been a growing interest in using infarct size as a surrogate endpoint for clinical trials assessing the efficacy of acute MI reperfusion treatments and MI size is reported to be a stronger predictor of outcome than LVEF and LV volumes.Various methods have been proposed for infarct size (IS) measurement without reference standard method and side-by-side comparison among them. The goal was to develop a user-friendly cardiac segmentation toolbox implemented as a plugin in the open-source OsiriX software with a set a commonly proposed semi-automatic algorithms
Contour segmentation was implemented using a fast automated segmentation framework (B-spline Explicit Active Surfaces) that could be corrected or manually performed. Several semiautomatic methods were implemented from simple image intensity threshold based on 1) histogram, or 2) equal to × standard deviation (xSD) above the mean of remote normal myocardial intensity 3) full-width at half-maximum (FWHM) with 2D/3D and maximum or region based variants. More sophisticated algorithms were also implemented including 4) the Gaussian Mixture Model (GMM) and 5) the method proposed by Hsu that assign a weighting to each voxel depending on its image intensity or use a combination of methods along with regional feature analysis. Performance of methods was 1) evaluated for precision and accuracy on a realistic phantom based on real datasets with varying contrast to noise ratio (CNR) between infarct aera and normal myocardium and 2) compared in-vivo on DE-CMR images in post-AMI patients.
CMRSegTools brings in a user friendly interface integrated as a plugin in the widely available advanced open-source OsiriX dicom workstation, a toolbox allowing to calculate, display and interactively analyze myocardial lesions and especially myocardial infarct lesions. CMRSegTools offers a fast, real-time and integrated process and advanced published algorithms for quantification purposes in CMR through an ergonomic interface. It can be proposed for newly available methods, as a plateform for algorithm performance comparison and validation.
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