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Heterogeneity of resting and hyperemic myocardial blood flow in healthy volunteers: a quantitative CMR perfusion pixel-map study
© Greve et al.; licensee BioMed Central Ltd. 2014
Published: 16 January 2014
An accurate description of the heterogeneity in myocardial blood flow (MBF) by CMR is needed for understanding the physiology of perfusion variability.
Quantitative CMR perfusion was performed at 1.5T in 17 healthy volunteers under baseline (rest) and adenosine hyperemia (stress). Median filters with different kernel size were used to estimate MBF at different resolutions (0.07 g, 0.27 g, 0.61 g, 1.1 g of myocardium). MBF heterogeneity was evaluated as the relative dispersion ([RD] = standard deviation/mean) on basal- and mid-ventricular slices for each subject. Paired t-tests and linear mixed-models were used to account for within-subject effects.
Healthy myocardium displays resolution-dependent hetereogeneity of MBF at rest that increases during hyperemia. MBF heterogeneity by quantitative CMR is lower than that reported by microsphere data for equal tissue weight. Furthermore, this analysis is, to the best of our knowledge, 4 times higher resolution than any microsphere or PET analysis.
This project was funded by the Intramural research program of the National Heart Lung and Blood Institute at the National Institutes of Health.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.