Cine-CMR quantified left atrial diameter - a simple index of left atrial remodeling that closely parallels chamber area and stratifies longitudinal atrial arrhythmic risk
© Kim et al.; licensee BioMed Central Ltd. 2014
Published: 16 January 2014
Cine cardiac magnetic resonance (cine-CMR) provides excellent endocardial delineation, enabling accurate quantification of left atrial (LA) chamber size. Relative utility of cine-CMR linear dimensions and area-based indices for prediction of LA-associated arrhythmias is unknown.
The study comprised patients with coronary artery disease (CAD) included in a multimodality registry. Cine-CMR (1.5T) was performed using a standard 2-dimensional steady state free precession (SSFP) pulse sequence (typical TR 3.5 msec, TE 1.6 msec, flip angle 60°, temporal resolution 30-50 msec). Cine-CMR evidenced mitral regurgitation (MR) severity was graded in accordance with established conventions based on size of MR associated inter-voxel dephasing of the regurgitant jet. LA size was measured on cine-CMR at atrial end-diastole using two established methods:  linear diameter (measured in 3-chamber long axis orientation),  area (planimetered in 4-chamber long axis orientation), with both indices indexed to body surface area. Clinical follow-up was performed via medical record review, with atrial fibrillation (AF) or flutter (AFl) verified based on physician documentation.
Cine-CMR quantified LA diameter provides a simple measure of atrial remodeling that correlates well with LA area, yielding similar predictive value for stratifying MR as well as longitudinal risk for atrial arrhythmias.
National Institutes of Health (K23 HL102249-01).
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