- Poster presentation
- Open Access
High-resolution quantitative spiral perfusion for microvascular coronary dysfunction detection
© Yang et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Myocardial Blood Flow
- Myocardial Perfusion Reserve
- Transmural Extent
- Microvascular Coronary Dysfunction
- Segment Myocardial Blood Flow
Quantitative first-pass CMR can assess the severity of microvascular coronary dysfunction(MCD) in subjects with signs and symptoms of ischemia but without obstructive coronary artery disease(CAD). In patients with MCD, abnormalities of myocardial perfusion reserve(MPR) occur globally but may also vary in their transmural extent. Thus, high spatial resolution quantitative CMR perfusion imaging is needed to differentiate between the subendocardial and subepicardial layers. Given the efficiency and SNR of spiral trajectories, we have developed the accelerated high-resolution absolute quantification spiral pulse sequence to assess variations in the transmural extent of myocardial perfusion abnormalities in patients with suspected MCD.
We developed an accelerated high-resolution perfusion pulse sequence based on our previous dual contrast quantitative spiral sequence. Sequence parameters included: 8 interleaves of variable density spirals from 0.75 to 0.2 Nyquist, 6.1 ms readout per interleaf, TE 1.0 ms, TR 9 ms, TI 80 ms, FA 35°, FOV 320 mm2, in-plane resolution 1.5 mm. Resting perfusion were collected in 5 volunteers and adenosine stress CMR was performed in one suspected MCD patient. Perfusion images were acquired at 3 short axis slice locations on a 1.5T Siemens Avanto scanner during injection of 0.1 mmol/kg of Gd-DTPA. Stress imaging was performed following a 4 minute infusion of adenosine(140 mcg/kg/min). Quantification of perfusion was performed on a pixel-wise basis using Fermi-function deconvolution after image was reconstructed by SPIRiT and aligned with non-rigid registration ANTS.
We demonstrate the successful application of high-resolution quantitative spiral perfusion sequence in both healthy volunteers and in a patient with suspected MCD. This technique provides high quality images and high resolution MBF to further investigate the transmural variation of MBF in patients with MCD and evaluate the prognostic significance of abnormal perfusion in these MCD patient subsets.
K23 HL112910, R01 HL79110
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