- Poster presentation
- Open Access
Left ventricular dyssynchrony can be observed via cine CMR with use of aortic valve timing
© Contijoch et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Aortic Valve
- Left Ventricular Outflow Tract
- Short Axis Image
- Ventricular Dyssynchrony
- Aortic Valve Closure
Cine CMR is the gold standard for evaluation of left ventricular function with high spatial and temporal resolution of the EKG-gated acquisition. Measurements of dyssynchrony have previously been performed using myocardial tagging to measure relative delays in peak shortening of opposing walls. We aim to utilize non-tagged images to quantify dyssynchrony in clinical patients. This is performed by combining aortic valve timing information from a left ventricular outflow tract (LVOT) image series with segmentations of short axis datasets.
The use of patients with prolonged QRS complexes allows for separation of measured dyssynchrony based on both EF and QRS. Patients were categorized into low EF (≤ 35%), mid EF (35% < EF < 50%) and normal EF (≥ 50%). The results are shown in Figure 1. As has been observed using tagged-MRI, patients with low EF demonstrate higher dyssynchrony than both EF-matched controls as well as patients with long QRS but normal EF.
This technique allows for a slice-by-slice timing based regional evaluation of dyssynchrony. In addition, subsequent analysis of particular dyssynchronous slices could be performed to provide additional regional information.
K99-HL108157, R01-HL103723, T32HL007954, T32-EB009384.
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