- Poster presentation
- Open Access
Native T1 and T2 values by Cardiovascular Magnetic Resonance Imaging in patients with systemic inflammatory conditions
© Hinojar et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Systemic Lupus Erythematosus
- Cardiovascular Magnetic Resonance
- Cardiovascular Magnetic Resonance Image
- Systemic Inflammatory Disease
- Cardiovascular Magnetic Resonance Study
Patients with systemic inflammatory diseases are at risk of heart failure due to sustained systemic inflammation leading to diffuse myocardial injury and left ventricular remodelling. Because native T1 and T2 values are raised in the presence of diffuse fibrosis and oedema, T1 and T2 mapping by cardiovascular magnetic resonance (CMR) are emerging as potential tools to assess diffuse myocardial involvement. In this study, we examined native T1 and T2 values in patients with systemic inflammatory diseases.
79 patients with a clinical diagnosis of systemic inflammatory disease (systemic lupus erythematosus (SLE, n = 46), rheumatoid arthritis (RA, n = 17), systemic sclerosis (SS, n = 9) and Wegener's granulomatosis (WG, n = 7) underwent CMR study for routine assessment of oedema, function and scar at 3-Tesla. 36 healthy subjects served as controls. Native T1 values were acquired using 3'3'5 MOLLI and measured conservatively within septal myocardium of midventricular short-axis slice (mSAX). T2 values were recorded from T2 maps based on GraSE sequence using equivalent cardiac geometry. We compared regional T2 values between patients and controls, and assessed associations with native T1 values.
We demonstrate that native T1 and T2 values are increased in patients with systemic inflammation compared to controls. We also demonstrate that T2 values have regional differences in the presence of diffuse involvement. Native T1 and T2 values may serve as an early marker of myocardial injury due to diffuse fibrosis and low grade of oedema.
We would like to acknowledge Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital National Health Service Foundation Trust. Dr. Rocio Hinojar was supported by the Fundacion Alfonso Martin Escudero.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.