- Poster presentation
- Open Access
Right ventricular wall motion abnormalities n Thalassemia Major patients
© Meloni et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Ejection Fraction
- Left Ventricle
- Right Ventricular
- Myocardial Fibrosis
Movement abnormalities in the left ventricle (LV) were shown to be not really frequent in thalassemia major (TM) patients but they were associated with age, myocardial iron overload, LV dilation and dysfunction, and myocardial fibrosis. No data are available about the prevalence and the correlates of right ventricular (RV) wall motion abnormalities. This study investigated the relationship between RV and LV motion abnormalities and between RV motion and function in a large cohort of well-treated TM patients.
CMR was performed in 1092 TM patients (537 male; 30.6 ± 8.5 years) enrolled in the Myocardial Iron Overload in Thalassemia (MIOT) Network. Cine images were acquired to evaluate wall motion and to quantify RV volumes and ejection fraction (EF).
Normal RV motion
33.9 ± 5.9
30.5 ± 8.6
RV end-diastolic volume index (ml/m2)
110.4 ± 48.2
83.4 ± 19.2
RV end-systolic volume index (ml/m2)
61.5 ± 29.6
32.5 ± 11.4
RV ejection fraction (%)
44.9 ± 10.1
61.4 ± 7.7
In TM patients movement abnormalities in the right ventricle were less frequent compared to the left ventricle, but were associated with age, sex, RV dilation and dysfunction.
The MIOT project receives "no-profit support" from industrial sponsorships (Chiesi Farmaceutici S.p.A. and ApoPharma Inc.). This study was also supported by: "Ministero della Salute, fondi ex art. 12 D.Lgs. 502/92 e s.m.i., ricerca sanitaria finalizzata anno 2006" and "Fondazione L. Giambrone".
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.