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Reproducibility of CMR right ventricle volumetric measurements is independent of reader experience under a standardized protocol


The right ventricle's complex geometry makes it challenging to measure its size and function. Though volumetric CMR is generally considered the gold standard, standardized reading protocols are necessary. We sought to investigate whether a specific reading protocol can supersede cardiology training in right ventricular (RV) measurements. We aimed to evaluate the reproducibility of RV measurements done by both an experienced and a novice CMR reader.


During a training period an experienced (Level III trained) CMR reader and a CMR novice (high school student) jointly interpreted 50 cine SSFP studies obtained in the left ventricular short-axis orientation as contiguous stack encompassing both ventricles in their entirety. The standardized endocardial tracing protocol was delimited by the pulmonary valve and the tricuspid valve planes; interpretation was augmented using cine-review and cross-referencing with orthogonal cine images. RV stroke volume (RVSV) and ejection fraction (RVEF) were calculated from end diastolic volume (RVEDV) and end systolic volume (RVESV). After the training period, we randomly selected 24 anonymized datasets from a representative sample (50% men; median age 63 years[range 48-78]), and the two readers independently read the studies twice, in a random order and on different days. Reproducibility was evaluated with coefficients of variation (CV) and concordance correlation coefficients (Rho).


Mean ± SD measurements and CV did not differ between the experienced and the novice reader, respectively, for RVEDV (124.4 ± 30.1 vs 125.0 ± 30.1 mL; CV: 0.05 vs 0.04; P = NS), RVESV (45.6 ± 14.4 45.8 ± 13.4 mL; CV: 0.11 vs 0.09; P = NS), RVSV (78.9 ± 18.8 vs 79.2 ± 18.7 mL; CV: 0.05 vs 0.03; P = NS), RVEF (63.6 ± 5.4 vs 63.4 ± 5%; CV: 0.04 vs 0.04: P = NS). The concordance correlation coefficients and 95% limits of agreement are shown in the Table 1.

Table 1 Intrarreader and interreader concordance correlation coefficients (Rho) and mean differences with 95% limits of agreement


All global volumetric CMR RV measurements were highly reproducible, suggesting that a standardized reading protocol overcomes the complex RV geometry. Background CMR level of training did not affect these results. The high reproducibility and feasibility of applying a specific training protocol may impact research, allowing smaller sample sizes and better logistics for reading as well as for serial clinical assessment.


Dr Murilo Foppa has received support from CAPES-Brazil (9601-11-2).

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Foppa, M., Ashrafi, A., Salton, C.J. et al. Reproducibility of CMR right ventricle volumetric measurements is independent of reader experience under a standardized protocol. J Cardiovasc Magn Reson 16 (Suppl 1), P272 (2014).

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