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- Open Access
Myocardial iron assessment by T1 cardiovascular magnetic resonance at 1.5 Tesla
© Alam et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Cardiovascular Magnetic Resonance
- Iron Overload
- Hereditary Hemochromatosis
Heart failure secondary to cardiac siderosis is the prevalent cause of mortality in patients with primary or secondary iron overload. Myocardial iron assessment using T2* has been successfully calibrated against myocardial iron at 1.5T and the black blood (BB) technique has demonstrated high reproducibility such that it has become the clinical gold standard. T1 appears to correlate with T2* in cases of significant iron loading (T2* < 20 ms) but this relationship weakens when T2* is in the normal range. We evaluated this further.
69 subjects (40 male, aged 14 to 81 years) comprising 20 healthy volunteers (controls) and 49 patients (thalassemia major 22, sickle cell disease 9, hereditary hemochromatosis 8, other iron overload conditions 10) referred for routine iron assessment were recruited. The same mid-ventricular short axis cardiac slice was used to acquire both BB T2* images and to generate T1 MOLLI maps for each subject at 1.5T (Avanto, Siemens AG Healthcare Sector, Erlangen, Germany). 20 subjects underwent repeat studies on the same day to evaluate reproducibility. Regions of interest were selected in the septum using CMRtools.
In this analysis, T1 mapping using a MOLLI sequence identified all those individuals with significant iron loading as defined by the current gold standard T2* technique and has excellent reproducibility. As expected, T1 can also identify patients with mild cardiac iron loading that is not considered clinically significant. It is possible that T1 may have a clinical role in non-cardiac conditions with very low levels of iron loading, where factors other than iron affect the T2* signal, however tissue calibration remains lacking at this time. Further work is needed to determine whether there might be clinically significant advantages of T1 over the T2* cardiac technique at 1.5T for assessment of cardiac iron, but there are none at this time.
This research was supported by the NIHR Cardiovascular Biomedical Research Unit at Royal Brompton & Harefield NHS Foundation Trust and Imperial College London.
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