- Poster presentation
- Open Access
Refining risk assessment in cardiac sarcoidosis: a role for burden of late gadolinium enhancement and right ventricular function
https://doi.org/10.1186/1532-429X-16-S1-P302
© Murtagh et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
Keywords
- Right Ventricular
- Cardiovascular Magnetic Resonance
- Sarcoidosis
- Late Gadolinium Enhancement
- Cardiac Sarcoidosis
Background
The presence of myocardial late gadolinium enhancement (LGE) in patients with sarcoidosis is a powerful predictor of major adverse events (MAE: death, ventricular tachycardia, or appropriate ICD therapy). In this study, we aim to determine if the burden of LGE, left ventricular (LV) and right ventricular (RV) end-diastolic and end-systolic volume index (EDVi & ESVi) and ejection fraction (EF) can be used to improve risk stratification in patients with cardiac sarcoidosis (CS).
Methods
Diagnosoft Virtue software was used to delineate areas of LGE (defined here as having a signal intensity > 5 standard deviations above that of normal remote myocardium).
Results
Functional and structural parameters for subjects with and without major adverse events
MAE + | MAE - | P value | |
---|---|---|---|
LVEF (%) | 59 ± 4 | 60 ± 4 | 0.53 |
LVEDVi (ml/m2) | 65 ± 22 | 27 ± 9 | 0.53 |
LVESVi (ml/m2) | 27 ± 9 | 28 ± 7 | 0.72 |
RVEF (%) | 42 ± 12 | 54 ± 9 | 0.01 |
RVEDVi (ml/m2) | 86 ± 22 | 72 ± 14 | 0.09 |
RVESVi (ml/m2) | 54 ± 18 | 34 ± 14 | 0.007 |
LGE (%) | 20 ± 20 | 7 ± 5 | 0.01 |
Conclusions
The burden of LGE and RV size and function (not LV size and function) further improve prediction of death and significant ventricular arrhythmia in patients with cardiac sarcoidosis
Funding
None.
Authors’ Affiliations
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.