- Poster presentation
- Open Access
Mechanical effects of midwall fibrosis in non-ischemic dilated cardiomyopathy
© Taylor et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Cardiac Death
- Sudden Cardiac Death
- Dilate Cardiomyopathy
- Late Gadolinium Enhancement
- Mechanical Effect
In patients with non-ischemic dilated cardiomyopathy (NIDCM), mid-wall fibrosis (MWF) is associated with a higher risk of hospitalizations and death from pump failure and sudden cardiac death. The mechanical effects of MWF remain unexplored. Strain measures derived from feature tracking-CMR (FT-CMR) have been validated against myocardial tagging.
Patients (n = 84, age: 57.7 ± 14.7 yrs, [mean ± SD], LVEF: 25.7 ± 11.1%) with newly diagnosed NIDCM underwent late gadolinium enhancement CMR (inversion-recovery technique 10 min after the administration of gadolinium-DTPA (0.1 mmol/kg). Peak systolic circumferential (Εcc) and radial (Εrr) strain were assessed using FT-CMR of the mid-cavity LV short-axis cine and peak systolic longitudinal strain (Εll) was assessed from the horizontal long axis cine.
In patients with NICM and comparable LVEF, MWF is associated with impaired myocardial contraction in a circumferential direction. These findings are likely to be useful in the prognostic stratification of patients with NICM. They may also account for the recently recognised negative effects of MWF in patients undergoing CRT.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.