- Poster presentation
- Open Access
Longitudinal and circumferential strain assesment of left and right ventricles in acute myocardial infarction superimposed with microemboli
© Suhail et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Longitudinal Strain
- Free Wall
- Circumferential Strain
- Reperfusion Therapy
- Microvascular Obstruction
Microvascular obstruction is a major problem after reperfusion therapy of AMI. A recent study reported that longitudinal and circumferential strain after reperfusion therapy is an excellent predictor of left ventricular (LV) dysfunction in patients with anterior wall AMI [1, 2]. In the current MRI investigation, we adapted a method routinely used in echocardiography for measuring LV, RV interventricular walls longitudinal strain . Furthermore, we developed a well-controlled AMI superimposed with microemboli model to study LV and RV strain changes and compared it with animals subjected to LAD microembolization or occlusion/reperfusion.
Pigs (n = 24) were subjected to either 90 min LAD occlusion plus delivery of 32 mm3microemboli then reperfusion (n = 8), LAD occlusion/reperfusion (n = 8) or microembolization (n = 8). Eight animals served as controls. Three days after interventions, 4-chamber view cine MRI (TR/TE/FA = 3.5 ms/1.75 ms/70) was performed in long-axis view for longitudinal strain and 2-chamber view tagged MRI (TR/TE/FA = 35/6.1 ms/25) for circumferential strain. Phasic and peak circumferential strain was analyzed using HARP. For viability imaging, delayed Gd-DTPA enhanced IR-GRE sequence was used (TR/TE/FA = 5 ms/2 ms/15°). Nonparametric Student and Dunn's multiple comparison tests were used.
MRI showed that segments in pre-existing AMI superimposed with microemboli have impairment in both strain, while segments with single insult showed only circumferential impairment. The interaction between LV and RV after interventions is clearly demonstrated on the RV strain, suggesting that both LV and RV need assessment in AMI.
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