- Poster presentation
- Open Access
Quantitative pixel-wise measurement of myocardial blood flow: a comparison of methods to correct for surface coil-related field inhomogeneity
© Miller et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Cardiovascular Magnetic Resonance
- Myocardial Blood Flow
- Invasive Coronary Angiography
- Dual Sequence
Pixel-wise quantitative analysis of cardiovascular magnetic resonance (CMR) perfusion images allows myocardial blood flow (MBF) to be measured at the level of approximately 30 μL of myocardium. However B1-field inhomogeneity, induced by phased array surface receiver coils, potentially confounds MBF measurements. The aim of this study was to compare the effect of: 1. no surface coil intensity correction (No-SCIC); 2. SCIC performed using saturation recovery steady-state free precession images (SSFP-SCIC); and 3. SCIC performed using proton density-weighted images (PD-SCIC); on pixel-wise measurements of MBF in patients with confirmed significant coronary artery disease (CAD) and healthy volunteers.
26 subjects, comprising 18 patients (11 male; age 58 ± 12 years) with significant CAD (> 70% stenosis on invasive coronary angiography) in 1 (56%) or 2 (44%) major epicardial arteries (78% LAD, 50% RCA, 17% Cx) and 8 healthy volunteers (7 male; age 24 ± 10 years), were included. Perfusion imaging was performed using a motion-corrected saturation recovery steady-state free precession, dual sequence method at 1.5T (Espree, Siemens Medical Solutions) during Regadenoson vasodilator stress and at rest, using 0.05 mmol/kg Gadolinium-DTPA. A proton density-weighted image was acquired at the beginning of the perfusion sequence. B1-field inhomogeneity was approximated using a third-order surface fit to myocardial and body signal intensities on the PD image or the first SSFP image. The estimated intensity bias field was subsequently applied to the image series. For No-SCIC analysis, only baseline normalisation was performed. Pixel-wise MBF was measured from mid-ventricular stress images.
This study demonstrates the importance of correcting for surface coil-related field inhomogeneity for pixel-wise MBF quantification. However, although PD-based SCIC led to lower spatial heterogeneity than SSFP-based SCIC, the difference in measured MBF between ischaemic and remote territories was similar for both methods, and thus either could be applied.
CAM is supported by the National Institute for Health Research, UK. LYH, AT, HC, SW and AEA are supported by the National Institutes of Health.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.