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- Open Access
Accelerated 2D multi-slice first-pass contrast-enhanced myocardial perfusion using through-time radial GRAPPA
© Hamilton et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Myocardial Perfusion
- Peak Enhancement
- High Acceleration Factor
- Volumetric Coverage
- Grappa Reconstruction
Non-Cartesian parallel imaging is a promising approach for reducing the scan time in multi-slice first-pass myocardial perfusion imaging, allowing increasing volumetric coverage in comparison with standard techniques. Through-time radial GRAPPA has previously been demonstrated for real-time functional cardiac imaging [Seiberlich, et al. MRM 2011 Feb;65(2):492-505]. In this work, the through-time radial GRAPPA technique is applied for the acquisition of fifteen slices per heartbeat during a contrast-enhanced myocardial perfusion examination.
Three healthy volunteers underwent first-pass myocardial perfusion imaging on a 3T Skyra scanner with a 34-channel array. For calibration of through-time radial GRAPPA, 26 frames of fully-sampled data were collected for 15 slices (scan time 2.7 minutes) without ECG gating or breath holds using the following parameters: radial FLASH sequence, 128×128 grid, TR = 2.94 ms, TE = 1.47 ms, FOV = 300 mm2, spatial resolution = 2.3 mm2, 8 mm slice thickness. After injection of contrast agent (Optimark, 0.1 mmol/kg, 3 mL/s), undersampled radial data with ECG gating were collected for 60 cardiac phases. For the accelerated scans, 12 projections per slice were collected (R = 16.8 with respect to the Nyquist limit), and volunteers were instructed to hold their breath for as long as possible. A non-selective saturation recovery pulse was played after each cardiac trigger, and data for all slices were collected within each cardiac phase after a set trigger delay. All other parameters were identical to the calibration scans. The through-time radial GRAPPA reconstruction was performed using 26 time repetitions and an 8×4 k-space segment, and data were gridded using an open-source NUFFT implementation [Fessler JA. JMRI 2007 Oct;188(2):191-195].
It has been demonstrated that through-time radial GRAPPA can be used for 2D multi-slice first-pass contrast enhanced myocardial perfusion. By using a high acceleration factor, up to fifteen slices can be imaged within each heartbeat.
NIH/NIBIB R00EB011527 and Siemens Medical Solutions.
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