- Poster presentation
- Open Access
Cine DENSE strain imaging of the right ventricle: improved methods and initial experience in heart failure
https://doi.org/10.1186/1532-429X-16-S1-P4
© Cui et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
Keywords
- Right Ventricular
- Heart Failure Patient
- Right Ventricular Function
- Radial Basis Function
- Right Ventricular Free Wall
Background
A user defined RV contour indicated in orange shown on (a) magnitude-reconstructed and (b, c) phase-reconstructed DENSE images encoded for (b) horizontal displacement and (c) vertical displacement. The Lagrangian strain calculated along the RV contour is described in (d).
Methods
Building upon prior methods for LV analysis [1, 2], we developed improved algorithms for semi-automatically analyzing RV strain. The first stage of RV analysis is anatomical delineation, locating DENSE observations attributable to underlying RV tissue. The algorithm requires user definition of RV anatomy on a single long-axis frame using a line contour (Figure 1a, b, c). Next, using a phase-quality-guided path-finding algorithm for phase unwrapping and using spatial interpolation with radial basis functions (RBF), the user-defined contour is propagated to all other cardiac phases through a process termed motion guided segmentation (MGS) [1]. With MGS, we project the manually defined RV contour to other cardiac phases using RBF interpolation of the displacement field. Lastly, material point trajectories are fit through time via a high order polynomial function. The final phase of RV analysis is strain estimation. Given the thin structure of the RV, we used a 1D contour strain, as illustrated in Figure 1. These new algorithms were applied to long-axis cine DENSE images acquired from 18 subjects without heart disease and 16 subjects with heart failure. Four data sets from HF patients were excluded due to aliasing artifacts. The RV was divided into two segments, namely the RV free wall and the septum.
Results
Mean RV contour strain for 18 subjects without heart disease (a. d) and 16 subjects with heart failure (b, e). Segmental data are shown for the RV free wall (a, b) and the septum (d, e). (c, f) RV peak contour strain for (c) the RV free wall and (f) the septum demonstrate dysfunction in heart failure patients compared to subjects without heart disease (*p < 0.01). All data shown are mean ± standard deviation.
Conclusions
The new DENSE analysis methods successfully propagated RV contours to sequential cardiac frames and computed RV contour strains. Using these methods, cine DENSE detected abnormal RV strain in HF patients compared to subjects without heart disease.
Funding
NIH K23 grant HL094761 and American Heart Association Grant-in-Aid 12GRNT12050301.
Authors’ Affiliations
References
- Spottiswoode B, et al: MIA. 2009Google Scholar
- Gilliam A, Epstein F: IEEE. 2012Google Scholar
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.