- Poster presentation
- Open Access
Numerically optimized radiofrequency pulses for robust and low-power cardiovascular T2 preparation at 3T
© van Heeswijk et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Cardiac Magnetic Resonance
- Specific Absorption Rate
- Nutation Angle
- Minimum Energy Requirement
- bSSFP Imaging
Cardiac magnetic resonance imaging (CMR) has been shown to benefit from the higher signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) available at higher magnetic field strengths; however, in practice, CMR remains limited by the need for higher radiofrequency (RF) pulse power, which is in turn limited by the maximum specific absorption rate (SAR). For example at 3T, an adiabatic (robust to RF inhomogeneity ΔB1) T2 preparation (T2Prep, Nezafat et al., MagnResonMed2006) can usually only be combined with balanced steady-state free precession (bSSFP) acquisitions with low nutation angles, or is played out only once every several heartbeats. Thus the design of T2Prep adiabatic inversion pulses requires a compromise between pulse performance and the energy deposition. To overcome this SAR limitation on T2Prep, we therefore numerically optimized two hyperbolic secant (HSn; Silver et al. JMagnReson1984) RF pulses and tested their performance for T2Prep refocusing in CMR at 3T.
A genetic algorithm based on Bloch equation simulations (Hurley et al., MagnResonMed2010) was used to numerically optimize standard adiabatic HS1 (higher power requirement and ΔB1 robustness) and HS8 pulses (lower power requirement and ΔB1 robustness) to generate Time-Resampled Frequency-Offset-Corrected Inversion (TR-FOCI) pulses with a duration of 12 ms and an inversion band of 300 mm, which should easily cover the cardiac anatomy. The minimum energy requirements for satisfactory T2Prep performance were assessed in agar-NiCl2 phantoms and 3 healthy volunteers with a 2D radial bSSFP imaging sequence (nutation angle 70°, matrix 2562, slice thickness 8 mm, lines per heartbeat 35) on a 3T clinical MR scanner (Skyra, Siemens) while monitoring SAR levels. The myocardium-to-blood CNR was calculated in both phantoms and volunteers and the minimum required pulse energy for constant CNR and absence of artifacts was compared.
We successfully implemented numerically optimized adiabatic pulses and demonstrated that they required less power for similar performance to HSn pulses in a T2Prep, which critically enables the use of CMR with bSSFP and T2Prep at 3T.
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