- Poster presentation
- Open Access
Carotid Multicontrast ATherosclerosis CHaracterization (MATCH) in a single scan
© Fan et al.; licensee BioMed Central Ltd. 2014
- Published: 16 January 2014
- Carotid Plaque
- Contrast Weighting
- Healthy Volunteer Study
- Normal Vessel Wall
- Loose Matrix
The conventional MRI protocol for the characterization of atherosclerotic plaques involves a series of scans that provide multiple contrast weightings for resolving high-risk plaque characteristics . However, mis-registration between image sets due to the inter-scan motion often compromises evaluation accuracy and image interpretation is expertise dependent . The aim of this work was to develop a 3D MRI technique that acquires multiple image sets in a single scan with distinct contrast weightings.
The developed MATCH sequence utilizes a low-flip-angle gradient echo-based MRI acquisition combined with magnetization preparative schemes, and multiple co-registered 3D image sets are collected in an interleaved scan with 4 TRs per cycle: the 1st TR provides hyper T1-weighted (T1w) contrast by using a nonselective inversion pulse and a blood-suppressing flow-sensitive dephasing (FSD) preparation ; the 2nd TR provides gray-blood lumen arising from both blood T1-recovery and in-flow fresh blood; the 3rd TR is for signal recovery without readout events, followed by the 4th TR for T2-weighted (T2w) contrast by using a long-duration FSD preparation. The three contrasts aims to identify the intra-plaque haemorrhage (IPH), juxtaluminal calcification (CA), loose matrix (LM), and potentially lipid core, respectively. The technique was optimized based on computer simulations and healthy volunteer studies and then evaluated on patients (n = 8) with carotid plaques on a 3T system (Siemens Verio). Imaging parameters include: 55-62 segments per TR of 1200 ms, flip angle = 8°, in-plane resolution = 0.55-0.63 mm, slice thickness = 2 mm, 18 slices, CHESS fat saturation, inversion time delay = 460-480 ms, m1 = 945 mTms2/m, FSD/T2 duration = 18/40 ms, centric reordering, iPAT = 2, scan time = 5-6 min. For comparison, spatially matched T1-w/T2-w TSE and TOF imaging were performed.
MATCH is a promising technique for an expedite and accurate characterization of carotid plaques. A large-scale patient validation is currently underway, using histology specimens as reference. Further technical improvements in spatial resolution and imaging speed will strengthen its clinical value.
NIH HL096119, AHH 11POST7650043.
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